Description
The ProbeSeq IL-6 PeptideProbe™ Targeting System enables selective molecular recognition of Interleukin-6 (IL-6), a central pro-inflammatory cytokine involved in immune regulation, infection response, and chronic inflammatory diseases.
IL-6 is a pleiotropic signaling protein secreted by immune cells including macrophages, T cells, and endothelial cells during inflammation and tissue injury. Elevated IL-6 levels are associated with sepsis, autoimmune disorders, cancer progression, and cytokine storm syndromes. Reliable detection tools are essential for biomarker monitoring, biosensor development, and multiplex diagnostic platforms.
This peptide-based targeting system provides high-specificity binding to IL-6, supporting rapid capture, quantification, and integration into electrochemical and microfluidic detection systems.
Biological Target Information
Target protein: Interleukin-6 (IL-6)
Molecular weight: approximately 21 kDa
Protein type: Pro-inflammatory cytokine
Biological source: Immune and stromal cells
Function: Immune regulation and inflammatory signaling
Clinical relevance: Sepsis, autoimmune disease, cancer, cytokine storm
The probe recognizes structural regions of IL-6 responsible for receptor interaction, enabling selective detection in biological samples.
Detection Mechanism
The peptide ligand binds specifically to IL-6 through engineered protein–peptide interactions. Target binding enables capture of IL-6 on functionalized surfaces, quantitative detection in biosensor platforms, signal generation in electrochemical and optical assays, and measurement of inflammatory biomarker levels.
Binding is optimized for stability in physiological buffers and complex biological matrices including serum and plasma.
Design Characteristics
High affinity toward IL-6 protein.
Minimal cross-reactivity with other cytokines.
Stable peptide conformation for reproducible performance.
Compatible with microfluidic and biosensor platforms.
Surface immobilization ready for gold, carbon, and polymer substrates.
Low non-specific adsorption.
Platform Compatibility
The IL-6 PeptideProbe™ integrates into immunoassays, electrochemical biosensors, microfluidic lab-on-chip devices, multiplex cytokine panels, and point-of-care detection systems.
Applications
Inflammation biomarker detection.
Cytokine monitoring studies.
Sepsis and infection research.
Immune response profiling.
Biosensor and diagnostic assay development.
Multiplex protein detection panels.
Product Specifications
Format: Synthetic targeting peptide
Purity: ≥95% (HPLC verified)
Storage: −20°C recommended
Stability: ≥12 months under recommended conditions
Use: Research Use Only (RUO)
