Description
The ProbeSeq C-Reactive Protein (CRP) Aptamer is a high-affinity single-stranded DNA (ssDNA) molecular recognition element engineered for selective binding to human C-reactive protein, an acute-phase protein produced by the liver in response to inflammation. This product supports research-use biosensing and diagnostic assay development applications, including inflammatory biomarker detection, cardiovascular risk assessment studies, and integration into rapid detection platforms.
C-reactive protein is widely recognized as a sensitive systemic biomarker of inflammation and tissue injury. CRP levels increase rapidly in response to infection, trauma, and chronic inflammatory conditions and are strongly associated with cardiovascular disease risk, autoimmune disorders, and metabolic syndrome. Sensitive detection of CRP is critical for inflammation monitoring research, disease progression studies, and development of rapid point-of-care diagnostic technologies.
This aptamer provides selective molecular recognition of CRP through sequence-defined binding interactions that support high target specificity and strong binding affinity under physiologically relevant conditions. Compared with antibody-based recognition elements, aptamers offer improved chemical stability, reproducible synthesis, and compatibility with electrochemical sensing platforms, surface functionalization strategies, and microfluidic diagnostic systems.
The aptamer sequence is optimized to minimize non-specific adsorption, support stable immobilization on sensing surfaces, and maintain binding performance across diverse assay environments, enabling reliable integration into biosensor development workflows and translational research platforms.
Typical assay workflows use sample input volumes ranging from approximately 5–50 µL depending on platform configuration, surface chemistry, and detection method. The aptamer is compatible with serum, plasma, and buffered sample matrices following appropriate assay optimization.
This product supports research programs focused on inflammatory disease research, cardiovascular biomarker detection, and biosensor engineering.
What’s Included
Each product contains:
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High-affinity ssDNA aptamer targeting human C-reactive protein
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Sequence documentation for research traceability
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Reconstitution guidelines and handling instructions
Custom sequence modifications and bulk quantities are available upon request.
Target Strategy
The aptamer is selected against human C-reactive protein to support:
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High binding specificity to CRP pentameric protein structure
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Minimal cross-reactivity with unrelated plasma proteins
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Stable performance under physiological buffer conditions
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Compatibility with biosensor surface immobilization strategies
Target selection prioritizes sensitivity and integration into diagnostic platforms.
Product Format
Available in two configurations:
Lyophilized format
• Delivered dry for enhanced stability
• Reconstitute in nuclease-free water or preferred buffer
Solution format
• Supplied at defined stock concentration (e.g., 100 µM)
• Provided in nuclease-free water or TE buffer
Custom concentrations and modification options available upon request.
Performance Orientation
Designed for compatibility with:
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Electrochemical biosensors
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Inflammation sensing platforms
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Optical and fluorescence-based detection systems
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Surface immobilization workflows
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Microfluidic and lab-on-chip systems
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Point-of-care inflammation monitoring devices
Quality Control
Each batch undergoes:
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Sequence verification
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Purity confirmation (HPLC purification)
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Concentration validation
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Manufacturing quality control review
Certificate of Analysis (CoA) available upon request.
Applications
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Systemic inflammation biomarker detection research
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Cardiovascular risk biomarker studies
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Infection and immune response monitoring research
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Biosensor development and validation
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Diagnostic assay development
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Microfluidic and point-of-care platform integration
Storage
Store at –20 °C.
Lyophilized aptamers are stable for up to 12 months. Avoid repeated freeze–thaw cycles for solution format.
