Description
The ProbeSeq Myeloperoxidase (MPO) Aptamer is a high-affinity single-stranded DNA (ssDNA) molecular recognition element engineered for selective binding to human myeloperoxidase. This product supports research-use biosensing and diagnostic assay development applications, including neutrophil extracellular trap (NET) formation studies, inflammatory response research, and integration into rapid detection platforms.
Myeloperoxidase is a heme-containing enzyme released by activated neutrophils and is widely recognized as a key biomarker of neutrophil activation and NET formation. MPO plays a central role in innate immune responses, oxidative stress pathways, and inflammatory disease progression. Detection of MPO is increasingly investigated in cardiovascular disease research, sepsis studies, autoimmune disease monitoring, and immune response characterization. Aptamer-based recognition provides a stable and reproducible alternative to antibody-based detection while supporting integration into electrochemical, optical, and microfluidic sensing platforms.
The aptamer sequence is selected to provide high target specificity, strong binding affinity, and reliable performance across diverse assay environments. Design parameters prioritize selective target recognition, reduced non-specific interactions, and compatibility with biosensor development workflows.
This aptamer supports translational research programs requiring robust molecular recognition elements for diagnostic technology development, biosensor integration, and advanced inflammatory biomarker detection studies.
What’s Included
Each product contains:
-
High-affinity ssDNA aptamer targeting human myeloperoxidase
-
Sequence documentation for research traceability
-
Reconstitution guidelines and handling instructions
Custom sequence modifications and bulk quantities are available upon request.
Target Strategy
The aptamer is selected against human myeloperoxidase to support:
-
High binding specificity to target protein
-
Minimal cross-reactivity with unrelated biomolecules
-
Stable performance across diverse buffer and assay conditions
-
Compatibility with biosensor surface immobilization strategies
Target selection prioritizes assay robustness and integration into diagnostic and sensing platforms.
Product Format
Available in two configurations:
Lyophilized format
• Delivered dry for enhanced stability
• Reconstitute in nuclease-free water or preferred buffer
Solution format
• Supplied at defined stock concentration (e.g., 100 µM)
• Provided in nuclease-free water or TE buffer
Custom concentrations and modification options available upon request.
Performance Orientation
Designed for compatibility with:
-
Electrochemical biosensors
-
Optical and fluorescence-based detection systems
-
Surface immobilization platforms
-
Microfluidic and lab-on-chip systems
-
Point-of-care diagnostic device development
-
Rapid assay prototyping workflows
Performance characteristics depend on assay configuration, surface chemistry, and experimental conditions.
Quality Control
Each batch undergoes:
-
Sequence verification
-
Purity confirmation (HPLC purification)
-
Concentration validation
-
Manufacturing quality control review
Certificate of Analysis (CoA) available upon request.
Applications
-
NET formation and neutrophil activation studies
-
Inflammatory biomarker detection research
-
Cardiovascular inflammation research
-
Sepsis and immune response studies
-
Biosensor development and validation
-
Diagnostic assay development
-
Microfluidic and point-of-care platform integration
Storage
Store at –20 °C.
Lyophilized aptamers are stable for up to 12 months under recommended storage conditions. Avoid repeated freeze–thaw cycles for solution format.
